FP422A NOVEL XANTHINE OXIDOREDUCTASE INHIBITOR TMX-049ATTENUATES RENAL INJURY IN ALBUMIN OVERLOAD INDUCED−NEPHROPATHY
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منابع مشابه
Renoprotective effect of the xanthine oxidoreductase inhibitor topiroxostat on adenine-induced renal injury.
The aim of the present study was to reveal the effect of a xanthine oxidoreductase (XOR) inhibitor, topiroxostat (Top), compared with another inhibitor, febuxostat (Feb), in an adenine-induced renal injury model. We used human liver-type fatty acid-binding protein (L-FABP) chromosomal transgenic mice, and urinary L-FABP, a biomarker of tubulointerstitial damage, was used to evaluate tubulointer...
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In addition to its critical role in purine metabolism, xanthine oxidoreductase (XOR) has been implicated in the development of tissue oxidative damage in a wide variety of respiratory and cardiovascular disorders such as acute lung injury, ischemia-reperfusion injury, atherosclerosis, heart failure, and arterial hypertension. Although much remains to be clarified about the regulation and signal...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2018
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfy104.fp422